发明名称 |
Exonuclease resistant terminally substituted oligonucleotides |
摘要 |
Compounds, compositions and methods for inhibiting gene expression are disclosed. The compounds comprise oligonucleotide sequences of from about 9 to about 200 bases having a diol at either or both termini. Preferred diols are polyalkyleneglycols, preferably polyethyleneglycols. Pharmaceutical compositions comprising the compounds and a physiologically acceptable carrier and methods of inhibiting gene expression in mammals comprising administering such compounds are also provided. Methods for inhibiting nuclease cleavage of compounds are also provided.
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申请公布号 |
US5245022(A) |
申请公布日期 |
1993.09.14 |
申请号 |
US19900562180 |
申请日期 |
1990.08.03 |
申请人 |
STERLING DRUG, INC. |
发明人 |
WEIS, ALEXANDER L.;OAKES, FRED T.;HAUSHEER, FREDERICK H.;CAVANAUGH, JR., PAUL F.;MOSKWA, PATRICIA S. |
分类号 |
C07H21/00 |
主分类号 |
C07H21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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