发明名称 2-AMINOPYRIMIDINE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THERAPEUTICS
摘要 Compounds corresponding to the general formula (I) <IMAGE> (I) in which n=2 or 3, X=H, F, Cl or OCH3, R=H or CH3, R1=H or CH3, R2=alkyl, hydroxyalkyl, (hydroxy)(methoxy)alkyl, dimethoxyalkyl, 2-(aminosulphonyl)ethyl, 2-(methylsulphonyl)ethyl, 2-(methylsulphonylamino)ethyl, aminocarbonylmethyl which is optionally substituted by nitrogen, phenylethyl which is optionally substituted, pyrimidinylaminoalkyl or arylcaronylaminoalkyl, or else R1 and R2 form, with the nitrogen which carries them, a piperidine, morpholine, thiomorpholine or piperazine ring, optionally substituted by nitrogen. Use in therapeutics.
申请公布号 US5244894(A) 申请公布日期 1993.09.14
申请号 US19920904060 申请日期 1992.06.26
申请人 SYNTHELABO 发明人 GEORGE, PASCAL;MANOURY, PHILIPPE;MARABOUT, BENOIT;FROISSANT, JACQUES;MERLY, JEAN-PIERRE
分类号 A61K31/505;A61K31/506;A61P13/00;A61P13/02;A61P13/08;A61P15/00;C07D239/42;C07D239/46;C07D295/13;C07D401/06;C07D401/12;C07D401/14;C07D403/12;C07D405/12 主分类号 A61K31/505
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