| 摘要 |
<p>A series of phenylalkylaminoalkyl derivatives of Formula I <CHEM> wherein Ar is naphtyl or phenyl; R<1> is hydrogen, fluoro or R<4>CONH-; R<2> is hydrogen or C1-6 alkyl; R3 is C1-6 alkyl; R<4> is C1-6 alkyl or phenyl- C1-6 alkyl; x is zero or the integers 1 and 2; m is selected from the integers 1 to 6; and n is selected from the integers 2 and 3, has been found to provide effective antiischemic protection for CNS tissue, particularly neurons. A method of treatment to protect against CNS ischemia, such as that resulting from trauma or stroke or other ischemic conditions, comprises administration of these novel compounds to an individual in need of such treatment.</p> |
