Esters of L-carnitine and acyl L-carnitine endowed with muscle relaxant activityselective on gastrointestinal tract and pharmaceutical compositions containing same.
摘要
<p>Esters of L-carnitine and acyl L-carnitine of formula (I): <CHEM> wherein R is hydrogen or is a straight or branched, saturated or unsaturated acyl group having 2 to 26 carbon atoms; R1 is a straight or branched, saturated or unsaturated alkyl group having 4 to 26 carbon atoms; and X<-> is the anion of a pharmacologically acceptable acid are endowed with potent muscle relaxant activity selective on the gastrointestinal tract and are therefore therapeutically useful for treating e.g. adaptive colitis syndromes.</p>
申请公布号
EP0559625(A2)
申请公布日期
1993.09.08
申请号
EP19930830083
申请日期
1993.03.01
申请人
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
发明人
SCAFETTA, NAZARENO;SANTANIELLO, MOSE;TINTI, MARIA ORNELLA;MISITI, DOMENICO;STASI, MARIA ANTONIETTA;VESCI, LOREDANA;CORSICO, NERIMA