1,4-DISUBSTITUTED PIPERIDINYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR METHODS OF PREPARATION

摘要

The present invention pertains to a new class of compounds which can be characterized as 1,4-disubstituted piperidinyl compounds of the formula: wherein Y is H, CO(CH2)nCH3, or SO2(CH2)nCH3 in which n is an integer from 0 to 3; X is CO, CHOH, or C=N-O-A, wherein A is hydrogen or a C1-4 alkyl; R is either selected from the group consisting of halogens, lower alkyl groups, lower alkoxy groups, and hydrogen or R is a divalent substituent and is a 3,4-methylenedioxy or a 3,4-ethylenedioxy substituent; and m is an integer from 1 to 5; or a pharmaceutically acceptable acid addition salt thereof. These compounds are useful as antiarrhythmics, analgesics, and serotonin 5HT2 antagonists.