| 摘要 |
PURPOSE:To obtain the temp. sensitive liposome which can release included materials at a specific temp. and is applicable in medical and pharmaceutical fields, such as drug carriers in drug delivery systems. CONSTITUTION:A high-polymer compd. having clouding points is deposited on or in the conventional lipid liposome to obtain the temp. sensitive liposome. The high-polymer compd. deposited on or in the liposome is hydrophobed at the temp. near the clouding point of such liposome and, therefore, disturbance is generated in the structure of the liposome film and the release of the included materials arises. The high-polymer compd. having the clouding points is adequately polyacrylic acid polymers, such as poly-N-isopropyl acrylamide. The high- polymer compd. is stably deposited on the liposome surface if a hydrophobic group, such as alkyl group or cholesterol, is introduced therein. |
