| 摘要 |
PURPOSE:To provide polymorphic piretanide which is useful as a diuretic agent characterized by the differential thermal curve, powder X-ray analysis and infrared spectroscopy. CONSTITUTION:The piretanide has the endothermic peak at about 213 deg.C, the exothermic peak at about 216 deg.C and the melting peak about 227 deg.C in the differential thermal curve; 20.1, 21.3, 23.1, 24.3 deg. of 2theta diffraction peaks in powder X-ray diffraction and absorptions at 1690 and 3250 to 3400cm<-1> in the infrared absorption spectroscopy. The piretanide is obtained by crystallizing lower aliphatic alcohol or cyclic ether to form the solvation bonds and heating them at room temperature to the boiling point of the solvent under reduced or normal pressure for over 1 hour. It is stable at elevated temperatures in high humidity, high soluble in water and shows high bioavailability. |
