| 摘要 |
<p>A polypeptide patterned on a fragment of wild type glycoprotein Ibα having a predetermined affinity for von Willebrand factor, said polypeptide having a modified sequence of amino acids relative to that of said fragment and an increased binding affinity, relative to said predetermined affinity, for von Willebrand factor, for example, wherein said modification comprises replacement of one or more amino acid residues of said fragment with one or more amino acid residues found at the equivalent sequence positions of glycoprotein Ibα as isolated from one or more humans with platelet-type von Willebrand disease; and, in addition, a process for producing from DNA encoding glycoprotein Ibα, or a fragment thereof, an aforementioned polypeptide which process includes, for example, use of a DNA sequence in which one or more wild type codons thereof are replaced by codons specifying one or more amino acid mutations found in the glycoprotein Ibα DNA sequence of one or more patients having platelet-type von Willebrand disease; and, in addition, a therapeutic composition which is effective in treating or inhibiting thrombosis comprising a pharmaceutically acceptable carrier and a polypeptide of the invention, and also a method of treating or inhibiting thrombosis in a patient which comprises administering to such patient an effective amount of said therapeutic composition.</p> |
