发明名称 |
PEPTIDYL DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1 beta CONVERTING ENZYME |
摘要 |
Novel peptidyl derivatives of formula (I) are found to be potent inhibitors of interleukin-1 beta converting enzyme (ICE). Compounds of formula (I) may be useful in the treatment of inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular system including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes. Compounds of formula (I) are also useful in treating the complications of infection (e.g., gram negative shock) and tumors in which IL 1 functions as an autocrine growth factor or as a mediator of cachexia. |
申请公布号 |
WO9316710(A1) |
申请公布日期 |
1993.09.02 |
申请号 |
WO1993US01321 |
申请日期 |
1993.02.12 |
申请人 |
MERCK & CO., INC. |
发明人 |
CHAPMAN, KEVIN, T.;MACCOSS, MALCOLM;MJALLI, ADNAN |
分类号 |
A61K38/00;C07K5/02;C07K5/06;C07K5/08 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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