| 摘要 |
(SEE FIGURE I) Compounds useful in inhibiting the biosynthesis of leukotrienes have structure ( I), where M is hydrogen, a pharmaceutically acceptable cation, or a metabolically cleavable group, R4 is alkyl, cycloalkyl o r -NR5R6, where R5 and R5 are hydrogen, alkyl cycloalkyl or alkanoyl, where A is a valence bond or is a straight or branched d ivalent alkylene group of from one to twelve carbon atoms, R2 and R3 are independently selected from hydrogen, straigh t or branched alkyl of from one to twelve carbon atoms, halogen, or trifluoroalkyl, and R1 is selected from phenoxy, pheny lthio, 2-, 3-, or 4-pyridyloxy, 1-, or 2naph-thyloxy, or 2-, 4-, 5-, or 8-quinolytoxy all optionally substituted with al kyl, haloalkyl, alkoxy, hydroxy or halogen.
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