INDOLE DERIVATIVES AS TESTOSTERONE-5-ALPHA-REDUCTASE INHIBITORS

摘要

A compound of formula (I), wherein R<1> is carboxy or protected carboxy, R<2> is hydrogen, lower alkyl or halogen, R<3> is aryl which may have suitable substituent(s), A is lower alkylene, X is methylene, -O- or -NH-, and Y is lower alkylene substituted by lower alkoxy, lower alkenylene or lower alkynylene; or Y-R<3> is alkyl, and a pharmaceutically acceptable salt thereof. The compound of the present invention is useful as a testosteron 5 alpha -reductase inhibitor and effective to testosteron 5 alpha -reductase mediated diseases such as prostatism, prostatic hypertrophy, prostatic cancer, alopecia, hirsutism (e.g. female hirsutism, etc.), androgenic alopecia (or malepattern baldness), acne (e.g. acne vulgaris, pimple, etc.), other hyperandrogenism, and the like.