发明名称 |
METHODS AND COMPOUNDS FOR PREVENTION OF GRAFT REJECTION |
摘要 |
Disclosed is a method of preventing graft rejection by inducing a state of local immunosuppression at the transplant site with expression of recombinant proteins by the allograft. Also disclosed is a protein suppressor factor that is secreted by cloned anergic T-cells, blocks interleukin 2 (IL-2) stimulated T-cell proliferation, has an apparent molecular weight of between 10 and 30 kilodaltons, can be inactivated by heating to 65 DEG C for 15 minutes, blocks interleukin 4 (IL-4) stimulated T-cell proliferation in vitro, is non-cytotoxic to T-cells, and does not inhibit the production of IL-2 by T-cells in vitro. |
申请公布号 |
WO9317043(A1) |
申请公布日期 |
1993.09.02 |
申请号 |
WO1993US01768 |
申请日期 |
1993.03.01 |
申请人 |
BRIGHAM & WOMEN'S HOSPITAL;BETH ISRAEL HOSPITAL ASSOCIATION |
发明人 |
STROM, TERRY;RUBIN-KELLEY, VICKIE, E.;LIBERMANN, TOWIA |
分类号 |
C12N15/09;A61K31/70;A61K38/00;A61K48/00;A61P37/06;C07H21/04;C07K14/47;C07K14/495;C07K14/52;C07K14/54;C07K14/705;C07K14/715 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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