发明名称 |
PREPARATION OF 19-NOR-VITAMINE D COMPOUND |
摘要 |
<p>A convergent synthesis of 19-nor-vitamin D compounds, specifically 19-nor-1 alpha ,25-dihydroxyvitamin D3, is disclosed. The synthesis can also readily be utilized for preparing other 1 alpha -hydroxylated 19-nor-vitamin D compounds. The key step in the synthesis is a suitable application of Lythgoe's procedure i.e. a Horner-Wittig reaction of the lithium anion of a phosphine oxide with a Windaus Grundmann ketone to give, after any necessary deprotection, the desired 19-nor-vitamin D compound.</p> |
申请公布号 |
JPH05221960(A) |
申请公布日期 |
1993.08.31 |
申请号 |
JP19920162101 |
申请日期 |
1992.05.28 |
申请人 |
WISCONSIN ALUMNI RES FOUND |
发明人 |
HEKUTAA EFU DERUUKA;HAINRITSUHI KEE SHIYUNOOZU;KATOU ERU PEERUMAN;RORUFU II SUUENSON |
分类号 |
A61K31/59;A61P35/00;C07C35/14;C07C35/17;C07C43/115;C07C49/497;C07C67/343;C07C69/732;C07C69/734;C07C69/74;C07C317/18;C07C401/00;C07D307/20;C07D309/12;C07F7/08;C07F7/18;C07F9/40;C07F9/53 |
主分类号 |
A61K31/59 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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