PROCESS FOR PRODUCING SPIRO/TETRAHYDROPYRROLO/1,2-A/PYRAZINE-4,3'-PYRROLIDINE)-DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME

摘要

Tetrahydropyrrolo[1,2-a]pyrazine-4-spiro-3'-pyrrolidine derivatives of the formula: wherein R<1> and R<2> are independently hydrogen, halogen, trifluoromethyl, alkyl having 1 to 6 carbon atoms, alkoxy having 1 to 6 carbon atoms, or nitro, and R<3> is hydrogen, halogen or alkyl having 1 to 6 carbon atoms, and pharmaceutically acceptable salts thereof, processes for preparation thereof, and pharmaceutical composition containing the same. Said compounds and their salts show excellent aldose reductase inhibitory activity and are useful for the prevention and treatment of diabetic complications.