PROCESS FOR PRODUCING HETEROCYCLIC IMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AS ACTIVE INGREDIENT

摘要

A compound of the formula : wherein R<1> is hydrogen, halogen, nitro, lower alkyl, lower alkoxy, amino or acylamino, R<2>, R<3> and R<4> are each hydrogen, halogen, nitro, cyano, lower alkyl, lower alkenyl, lower alkylthio, mono or di or trihalo(lower)alkyl, oxo(lower)alkyl, hydroxy(lower)alkyl or optionally esterified carboxy; or R<2> and R<3> are linked together to form 1,3-butadienylene, R<5> is hydrogen or imino-protective group, R<6> and R<7> are each hydrogen or lower alkyl, R<8> is hydrogen or lower alkyl which may have a substituent selected from the group consisting of halogen and lower alkoxy, A is lower alkylene, Q is CH or N, X is N or CH, Y is NH, O or S, and Z is NH, S, SO2 or O. and pharmaceutically acceptable salt thereof, processes for their preparation and pharmaceutical compositions comprising them as an active ingredient.