发明名称 VERFAHREN ZUR HERSTELLUNG VON IBUPROFEN.
摘要 A process is provided for the preparation of ibuprofen enriched in R isomer, which comprises subjecting an ester of ibuprofen, to the action of a micro-organism or substances derived thereof, that will stereoselectively hydrolyse the ester to form ibuprofen predominantly having R configuration.
申请公布号 DE3882453(D1) 申请公布日期 1993.08.26
申请号 DE19883882453 申请日期 1988.06.30
申请人 GIST-BROCADES N.V., DELFT, NL;SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V., DEN HAAG/S'GRAVENHAGE, NL 发明人 BERTOLA, MAURO ATTILIO, NL-2624 PJ DELFT, NL;DE SMET, MARIE JOSE, NL-2803 EK GOUDA, NL;MARX, ARTHUR FRIEDRICH, NL-2614 GM DELFT, NL;PHILLIPS, GARETH THOMAS, SITTINGBOURNE KENT, GB
分类号 C12N1/20;C12N9/16;C12N9/18;C12N15/55;C12P7/40;C12P17/00;C12P41/00;C12R1/02;C12R1/07;C12R1/085;C12R1/445 主分类号 C12N1/20
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