发明名称 |
New process for the production of ceftriaxone. |
摘要 |
<p>The invention relates to a new process for the production of the disodium salt hemiheptahydrate of ceftriaxone by reacting 7-amino-3-{[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)t hio]methyl}-3-cephem-4-carboxylic acid with 2-(2-aminothiazol-4-yl)-2-syn-methoximinoacetic acid-(2-benzthiazolyl)thiolester in the presence of a base, characterized in that the reaction and the crystallization of the disodium salt hemiheptahydrate of ceftriaxone are carried out in aqueous acetone.</p> |
申请公布号 |
EP0556768(A2) |
申请公布日期 |
1993.08.25 |
申请号 |
EP19930102381 |
申请日期 |
1993.02.16 |
申请人 |
BIOCHEMIE GESELLSCHAFT M.B.H. |
发明人 |
DANKLMAIER, JOHANN;MACHER, INGOLF;PRAGER, BERNHARD |
分类号 |
C07D277/20;C07D277/40;C07D501/00;C07D501/06;C07D501/18;C07D501/36 |
主分类号 |
C07D277/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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