发明名称 |
VARICELLA-ZOSTER VIRUS AS A LIVE RECOMBINANT VACCINE |
摘要 |
<p>A vaccine strain of varicella-zoster virus (VZV), tested in clinical trials, is capable of preventing chickenpox in children. This virus has been modified by the introduction into its genome of heterologous DNA which encodes an immunogenic polypeptide of another human pathogen. This heterologous polypeptide is expressed in cells infected by the recombinant virus. Such recombinant VZV is useful as a vaccine for chickenpox as well as for heterologous pathogens.</p> |
申请公布号 |
EP0251534(B1) |
申请公布日期 |
1993.08.25 |
申请号 |
EP19870305202 |
申请日期 |
1987.06.12 |
申请人 |
MERCK & CO. INC. |
发明人 |
ELLIS, RONALD W.;SCOLNICK, EDWARD M.;KIEFF, ELLIOTT;LOWE, ROBERT S. |
分类号 |
A61K39/245;A61K39/00;A61K39/25;A61K39/295;A61P31/12;C07K14/02;C07K14/03;C12N7/04;C12N15/00;C12N15/09;C12N15/869;C12R1/92 |
主分类号 |
A61K39/245 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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