发明名称 |
PREPARATION OF LIPIDIC MICROPARTICLES |
摘要 |
<p>The invention relates to a method for the preparation of lipid microparticles, microcrystalline in appearance, of a water-insoluble substance exhibiting an affinity for phospholipids and at least one phospholipid, the microparticles being stable in suspension in an aqueous solution, wherein: … … a) the abovementioned substance and the abovementioned phospholipid(s) are dissolved in an organic solvent which is a common solvent for the substance and the phospholipid(s), … b) the solution of the substance and of the phospholipid(s) is mixed with an aqueous solution in a quantity such that an insolubilisation in the form of a precipitate takes place, … c) a separation is carried out so as to recover an aqueous solution containing the microparticles in the form of microsuspensions. … </p> |
申请公布号 |
EP0418153(B1) |
申请公布日期 |
1993.08.25 |
申请号 |
EP19900402509 |
申请日期 |
1990.09.12 |
申请人 |
THE LIPOSOME COMPANY, INC. |
发明人 |
LECLEF, BRIGITTE;CERFONTAINE, PATRICK;NICOLAS, JEAN-MARIE;WANTIER, HENRI;TROUET, ANDRE |
分类号 |
A61K9/14;A61K9/107;A61K9/127;A61K9/16;A61K9/51;A61K9/52;A61K31/70 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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