DNA encoding human CU/ZN superoxide dismutase muteins with at least serine or alanine at either or both residues 6 and 111

摘要

A polypeptide represented by the following general formula (I): X1AlaThrLysAlaValX2ValLeuLys (I) GlyAspGlyProValGlnGlyIleIleAsn PheGluGlnLysGluSerAsnGlyProVal LysValTrpGlySerIleLysGlyLeuThr GluGlyLeuHisGlyPheHisValHisGlu PheGlyAspAsnThrAlaGlyCysThrSer AlaGlyProHisPheAsnProLeuSerArg LysHisGlyGlyProLysAspGluGluArg HisValGlyAspLeuGlyAsnValThrAla Asp LysAspGlyValAlaAspValSerIle GluAspSerValIleSerLeuSerGlyAsp HisX3IleIleGlyArgThrLeuValVal HisGluLysAlaAspAspLeuGlyLysGly GlyAsnGluGluSerThrLysThrGlyAsn AlaGlySerArgLeuAlaCysGlyValIle GlyIleAlaGln wherein X1 means a hydrogen atom, acetyl group of amino acid residue, X2 and X3 are either the same or different and mean individually an amino acid residue, and when X2 stands for Cys, X3 denotes an amino acid residue other than Cys.