| 摘要 |
The invention relates to the use of alcohol derivatives of F-type prostaglandins as ocular hypotensives. The PGF derivatives used in accordance with the invention are encompassed by the following structural formula (I) <IMAGE> wherein wherein wavy line attachments indicate either the alpha ( alpha ) or beta (b) configuration; hatched lines indicate alpha configuration, solid triangles are used to indicate b configuration, dashed bonds represent a double bond, the 5,6-double bond being in cis-configuration, or a single bond; R is hydrogen or a -(CO)R4 group; R1, R2, and R3 independently are hydroxyl, or -O(CO)R5 groups, wherein R4 and R5 independently stand for saturated or unsaturated acyclic hydrocarbon having from 1 to 20 carbon atoms, or -(CH2)nR6 where n is 0-10 and R6 is an aliphatic, aromatic or heteroaromatic ring, R7 and R8 independently are hydrogen or alkyl of one to 6 carbon atoms or pharmaceutically acceptable salts thereof.
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