发明名称 |
BIOLOGICAL SENSORS |
摘要 |
A sensor using the principle of surface plasmon resonance (SPR) to monitor the progress of the reaction between a sample (not shown) and a sensitive layer 20 (for example an antibody layer). The layer 20 is applied to the rear surface of a metallic film 19 formed on the surface of an optically transmissive component 28 in the form of a hemicylindrical lens 11 and slide 16. Collimated light from a source (not shown) is applied via a lens 2 which focusses the incoming beam 1 to a focus at point 3 to form a fanshaped spread of light incident at point 3. The light is internally reflected at point 3, and emerges from the component 28 to be applied to a detector array 18 which latter is electronically scanned. The angle of incidence of the light at the point 3 is such as to span that angle which gives rise to surface plasmon resonance, together with a range of angles thereabout so that the progress of the resonant condition, as the reaction between the sample and the sensitive layer proceeds, can be monitored. Figure 3 |
申请公布号 |
CA1321488(C) |
申请公布日期 |
1993.08.24 |
申请号 |
CA19880574605 |
申请日期 |
1988.08.12 |
申请人 |
AMERSHAM INTERNATIONAL PLC |
发明人 |
FINLAN, MARTIN F.;MIDGLEY, JOHN E. M.;CHARLES, STEPHEN A.;IRLAM, JAMES C. |
分类号 |
G01N21/27;G01N21/41;G01N21/55;G01N33/543 |
主分类号 |
G01N21/27 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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