| 摘要 |
3-Arylindole or 3-arylindazole derivatives having general formula (I) wherein Ar is optionally substituted phenyl or a hetero aromatic group; R<1>-R<4> are hydrogen, halogen, alkyl, alkoxy, hydroxy, alkylthio, alkylsulfonyl, alkyl- or dialkylamino, cyano, trifluoromethyl, or trifluoromethylthio; X is N, CR<6>, R<6> being H, halogen, trifluoromethyl or alkyl, or CH2; Y is N, CH or C; R<5> is H, alkyl, alkenyl, cycloalkyl, or cycloalkylalkyl, or R<5> is a substituent of formula (1a) or (1b), wherein n is 2 - 6; W is O or S; U is N or CH; Z is -(CH2)m-, -CH=CH-, phenylene, -COCH2-, or -CSCH2-; V is O, S, CH2 or NR<7> wherein R<7> is H, alkyl, alkenyl, cycloalkyl or cycloalkylalkyl; U<1> is O, S, CH2 or NR<8>; and V<1> is NR<9>R<10>, OR<11>, SR<12> or CR<13>R<14>R<15>, where each of R<8>-R<15> are as defined for R<7>; inhibit the firing of spontaneously active dopamine neurones in the ventral tegmental area of the brain and are thus useful for the treatment of psychoses in humans. |
