NEUE LIPIDPHOSPHONSAEURE-NUCLEOSID-KONJUGATE SOWIE DEREN VERWENDUNG ALS ANTIVIRALE ARZNEIMITTEL

摘要

New phospholipidic derivates of nucleosides have general formula (I), in which R1 is a straight or branched, saturated or unsaturated alkyl chain with 1-20 carbon atoms, which may if required be substituted one or several times by phenyl, halogen, C1-C6-alkoxy, C1-C6-alkylmercapto, C1-C6-alkoxycarbonyl, C1-C6-alkylsulfinyl or C1-C6-alkylsulfonyl groups; R2 is a straight or branched, saturated or unsaturated alkyl chain with 1-20 carbon atoms, which may if required be substituted one or several times by phenyl, halogen, C1-C6-alkoxy, C1-C6-alkylmercapto, C1-C6-alkoxycarbonyl or C1-C6-alkylsulfonyl groups; X is a valency bond, oxygen, sulphur, the sulfinyl or the sulfonyl group; Y is a valency bond, an oxygen or sulphur atom; Z can be oxygen or sulphur, and Nuc is a residue derived from a nucleoside derivate. Also disclosed are the tautomers of these compounds and their physiologically tolerable salts of inorganic and organic acids or bases, as well as a process for preparing the same and medicaments containing these compounds.