发明名称 |
PROCESS FOR PRODUCING PROSTAGLANDIN E |
摘要 |
<p>To produce a prostaglandin E in a short time and in a high yield while minimizing the formation of isomers. A process for producing a prostaglandin E represented by general formula (I) wherein A represents an arbitrary group not participating in the reaction; B represents vinylene or ethynylene; R<4> and R<5> may be the same or different from each other and each represents hydrogen or a protective group for a hydroxyl group; and R<6> and R<7> represent each an arbitrary group not participating in the reaction, which comprises reacting an allyl ester of a prostaglandin E represented by general formula (II) wherein R<1> and R<2> may be the same or different from each other and each represents hydrogen or lower alkyl; R<3> represents hydrogen, lower alkyl, alkenyl or aryl; and R<4>, R<5>, R<6>, R<7>, A and B are each as defined above, with one or two compounds selected from the group consisting of bases and formic acid in the presence of a complex compound or a complex salt of 0-valent or divalent palladium atom.</p> |
申请公布号 |
WO9316041(A1) |
申请公布日期 |
1993.08.19 |
申请号 |
WO1993JP00115 |
申请日期 |
1993.02.02 |
申请人 |
TAISHO PHARMACEUTICAL CO., LTD.;SATO, FUMIE |
发明人 |
SATO, FUMIE;AMANO, TAKEHIRO;KAMEO, KAZUYA;TANAMI, TOHRU;MUTOH, MASARU;ONO, NAOYA;GOTO, JUN |
分类号 |
B01J31/22;B01J31/24;C07B61/00;C07C405/00 |
主分类号 |
B01J31/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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