USE OF 5,5'-DITHIO-BIS(2-NITROBENZOIC ACID) FOR INHIBITION OF HIV PROTEASE

摘要

A method and composition for inhibiting the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1, through reaction with the viral protease on an exposed surface, in particular an exposed surface outside of the active site of the viral protease, which method preferably involves contacting the virus with a composition comprising a sulfhydryl-reactive compound, such as 5,5'-dithio-bis(2-nitrobenzoic acid).