BACTERIAL MACROMOLECULE EXTRACT, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITION CONTAINING SAID EXTRACT

摘要

A modified bacterial protein-based extract comprising a mixture of acidic bacterial polyanions having a molecular weight of 10,000-1,000,000 and an isoelectric point of 2.5-5.5, wherein the sum of the constituent amino acids represents at least 50 wt % of said extract. Said protein extract is prepared by cultivating bacteria in an aqueous medium, subjecting the bacterial suspension to alkaline extraction and purifying the protein extract. Alkaline extraction is performed in the presence of a dilute aqueous source of OH<-> ions and at a pH of 11-13, with the pH decrease during said extraction being no greater than 0.4. The resulting protein extract may be used as an active ingredient in a pharmaceutical composition.