发明名称 |
BIOSYNTHETIC BINDING PROTEIN FOR CANCER MARKER |
摘要 |
2129663 9316185 PCTABScor01 Disclosed is a single-chain Fv (sFv) polypeptide defining a binding site which exhibits the immunological binding properties of an immunoglobulin molecule which binds c-erbB-2 or a c-erbB-2-related tumor antigen, the sFv includes at least two polypeptide domains connected by a polypeptide linker spanning the distance between the C-terminus of one domain and the N-terminus of the other, the amino acid sequence of each of the polypeptide domains includes a set of complementarity determining regions (CDRs) interposed between a set of framework regions (FRs), the CDRs conferring immunological binding to the c-erbB-2 or c-erbB-2-related tumor antigen.
|
申请公布号 |
CA2129663(A1) |
申请公布日期 |
1993.08.19 |
申请号 |
CA19932129663 |
申请日期 |
1993.02.05 |
申请人 |
CREATIVE BIOMOLECULES INC;CETUS ONCOLOGY CORP |
发明人 |
HUSTON JAMES S;HOUSTON L L;RING DAVID B;OPPERMANN HERMANN |
分类号 |
C12N15/09;A61K39/395;A61K49/00;A61K51/00;A61K51/08;A61P35/00;C07H21/04;C07K16/22;C07K16/28;C07K16/30;C07K16/32;C07K16/46;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/13;C12N15/62;C12N15/66;C12P21/02;C12P21/08;C12R1/19;(IPC1-7):C12N15/13;A61K43/00;A61K47/48 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|