AZABICYCLO DERIVATIVES,PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

摘要

PCT No. PCT/JP93/00469 Sec. 371 Date Sep. 21, 1994 Sec. 102(e) Date Sep. 21, 1994 PCT Filed Apr. 9, 1993 PCT Pub. No. WO93/21186 PCT Pub. Date Oct. 28, 1993A compound of the formula: in which R1 is carboxy or protected carboxy, R2 is 1-hydroxyethyl, R3 is methyl, R4 is optionally substituted pyridyl(lower)alkyl, optionally N-substituted 2-oxopiperazin-1-yl-(lower)alkyl, optionally substituted imidazol-1-yl(C2-C3)alkyl, optionally substituted imidazol-5-yl-(lower)alkyl, optionally substituted imidazol-2-yl-(lower)alkyl, optionally substituted pyrazol-4-(or 5-)yl(lower)alkyl, optionally substituted pyrazol-1-ylethyl, optionally substituted triazolyl(lower)alkyl, optionally substituted pyrimidinyl(lower)alkyl, optionally substituted dihydropyrimidinyl(lower)alkyl, or optionally substituted (2,3-dihydroimidazo-[1,2-b]pyrazol-1-yl)ethyl, and R5 is hydrogen or imino-protective group, and pharmaceutically acceptable salts thereof, which have antimicrobial activity.