Novel amidinonaphthyl furancarboxylate derivatives and acid addition salts thereof.

摘要

Amidinonapththyl furancarboxylate derivatives of the formula I <CHEM> wherein A is a single bond or A denotes a) a phenyl group, a cyclopentyl group or a cyclohexyl group; b) an alkenylphenyl group, an alkylphenyl group, a phenylalkenyl group or a phenylalkyl group wherein alkyl is C1 to C7 alkyl and alkenyl is C1 to C7 alkenyl; c) a C1 to C18 alkyl or C1 to C7 alkenyl group, which may be substituted by one or two substituents selected from C1 to C5 alkyl groups and guanidino groups, wherein an alkyl substituent together with the carbon atom to which it is attached, may form a cycloalkyl ring having from 3 to 6 carbon atoms, or a C1 to C5 alkyl may itself be substituted by a cycloalkyl ring; or d) -(CH2)n-NH-CO-(CH2)n<'>- wherein n and n', which may be the same or different, each represent an integer from 1 to 4; and R denotes a hydroxyl group; a C1 to C7 alkoxy group which may be mono- or di-substituted by C1 to C5 alkyl; a phenyl-C1-C4alkoxy group; -OAl(OH)2; an amino group; <CHEM> and pharmaceutically acceptable acid addition salts thereof are useful as pharmaceuticals.