VERFAHREN ZUR RACEMATTRENNUNG VON VERAPAMIL

摘要

The method proposed for separating racemates of verapamil is characterized in that the free base of the compound is reacted with optically active dibenzoyltartaric acid or ditoluoyltartaric acid in the molar ratio 1:1 to 1:2 in a mixture of methanol and water in the ratio 1:1 to 3:1 or in a mixture of acetone and water in the ratio 0.5:1 to 2:1, the diastereomeric mixture thus obtained is separated by crystallization, the diastereomers subsequently converted into their respective free bases and these optionally converted into their salts with physiologically tolerated acids.