发明名称 |
Thioether conjugates. |
摘要 |
<p>Provided are drug/ligand compounds of Formula (I): <CHEM> in which D is a drug moiety; n is an integer from 1 to 10; p is an integer from 1 to 6; Y is O or NH2<+>C1<->; z is 0 or 1; q is about 1 to about 10; X is a ligand; and, A is a Michael Addition Adduct. In a preferred embodiment, the ligand is an immunoglobulin, preferably a chimeric antibody or fragment thereof. Also provided are formulations comprising as an active ingredient a compound of Formula (I), intermediates useful for preparing the compounds of Formula (I), processes for preparing the compounds of Formula (I), and methods for using the compounds of the invention.</p> |
申请公布号 |
EP0554708(A1) |
申请公布日期 |
1993.08.11 |
申请号 |
EP19930100732 |
申请日期 |
1993.01.19 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
WILLNER, DAVID;TRAIL, PAMELA A.;KING, DALTON H.;HOFSTEAD, SANDRA J.;GREENFIELD, ROBERT S.;BRASLAWSKY, GARY R. |
分类号 |
A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61K31/7042;A61K31/7048;A61K39/395;A61K47/48;A61P35/00;A61P35/04;C07G11/00;C07H15/252;C07H17/04;C07K1/113;C07K14/00;C07K14/42;C07K14/485;C07K14/495;C07K14/52;C07K14/54;C07K14/55;C07K14/575;C07K14/62;C07K14/65;C07K14/705;C07K16/00;C07K19/00 |
主分类号 |
A61K31/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|