| 摘要 |
<p>PURPOSE:To provide the subject conjugate having a specific structure, exhibiting excellent microcirculation property and organotaxis and useful for a drug delivery carrier, etc. CONSTITUTION:The objective conjugate has a peptide skeleton of formula I {n is 0-2; (AA)n is one single bond when n is 0, group of formula II, etc., when n is 1, and group of formula III, etc., when n is 2; X<1>,...X<n>H are OR<1> or NHR<2> bonding to the carbonyl group in (AA)n or R bonding to the oxy group in (AA)n [R<1> is H, alkali metal, 1-3C alkyl, etc.; R<2> is H, (CH2)aOR (a is 1-10), etc.; R is (acetyl-protected) glycosyl]; Y is H, benzyloxycarbonyl, t- butoxycarbonyl, etc., bonding to the amino group in (AA)n}. The conjugate can be produced e.g. by reacting an amino-protected amino acid with a suger chain amine of the bonding group X, removing the protecting group and reacting a corresponding lipid carboxylic acid to the bonding group Y. A fine particular carrier can be produced from the conjugate.</p> |
