| 摘要 |
A new class of anti-craving compositions is provided by including, in such compositions, substances which inhibit the destruction of neuropeptidyl opiates. In one aspect, an anti-craving composition is provided by including, in such compositions, substances which inhibit breakdown of endogenous substances, e.g. enkephalins and/or endorphins. An anti-alcohol craving effect is observed with an enkephalen breakdown inhibitor. Specifically, D-phenylalanine, DL-phenylalanine, Dleucine, DL-leucine, and hydrocinnamic acid, each an encephalin breakdown inhibitor, significantly lower alcohol intake in animals and humans. The anti-alcohol desire effect is observed in animals genetically prone to choose alcohol over water solutions. |
