发明名称 |
FREMGANGSMAADE TIL FREMSTILLING AF OPTISK AKTIVE S(-)-CARBAZOLDERIVATER, NYE S(-)-CARBAZOLDERIVATER, SAMT LAEGEMIDLER, DER INDEHOLDER DISSE FORBINDELSER |
摘要 |
A process for the preparation of S- or R-carbazole derivatives of the general formula: <IMAGE> in which R is an unsubstituted or substituted amino radical and pharmacologically acceptable salts, by either reacting R-(-)-epichlorohydrin (for the S-carbazole derivative); or reacting an S-epoxide derivative of the general formula: <IMAGE> in which R1 is the residue of a substituted sulphonic acid derivative (for the R-carbazole derivative); with 4-hydroxycarbazole and then with ammonia or a substituted amine of the general formula RH, and recovering the compound or converting it to a pharmacologically acceptable salt. The new R-(+)- and S-(-)-carbozole derivatives provided by the inventive process have unexpected beta blocking and vasodilatory properties and are useful in pharmaceutical compositions. R-(+)-carbazole derivatives are also useful for the treatment of glaucoma. |
申请公布号 |
DK91393(D0) |
申请公布日期 |
1993.08.06 |
申请号 |
DK19930000913 |
申请日期 |
1993.08.06 |
申请人 |
BOEHRINGER MANNHEIM GMBH |
发明人 |
LEINERT, HERBERT |
分类号 |
A61K31/40;A61K31/403;A61K31/44;A61K31/4427;A61K31/443;A61P9/08;A61P9/12;A61P25/02;C07C29/09;C07D209/56;C07D209/88;C07D303/08;C07D303/12;C07D303/14;C07D303/16;C07D317/20;C07D401/12;C07D405/12;C07D491/056 |
主分类号 |
A61K31/40 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|