| 摘要 |
<p>This invention provides a method for stimulating or inhibiting the proliferation of differentiated macrophages by modulating the amount or activity of TGF-β in contact with said differentiated macrophages, as by contact with an effective amount of M-CSF or GM-CSF and TGF-β. The invention further provides a method for treating an individual with a condition characterized by the overabundance or lack of adequate differentiated macrophages by modulating the amount or activity of TGF-β activity in macrophage-containing tissues of said individual, as by administering an effective amount of M-CSF or GM-CSF and TGF-β, or by contacting differentiated macrophages with an agent, such as an antibody or decorin, which suppresses the activity of TGF-β. Further, the invention provides methods for stimulating proliferation of immature macrophages by contact with TGF-β.</p> |
