COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS

摘要

Compounds of formula (I) in which W is -CH2-, a bond, O or S; k is 0, or when W represents -CH2- k may also be 2, in which case the dotted lines represent single bonds; R is C1-8alkyl(phenyl)p, C2-8alkenyl(phenyl)p, C2-8alkynyl(phenyl)p, C3-8cycloalkyl or C1-8alkylC3-8cycloalkyl, or R may also represent hydrogen when k is 2; p is 0 to 2; n is 0 to 6; m is 0 to 6; and A is a bond, -CH=CH- or -C=C- oxygen, sulphur or NR<1>; R<1> is hydrogen, C1-8alkyl or phenylC1-4alkyl; and Ar is aryl or heteroaryl, each of which may be optionally substituted; with the provisos that: when W is a bond the side chain is alpha to the ring nitrogen atom; when W is CH2, k is zero, the side chain is at the 3- or 4-position of the piperidine ring and A is a bond, oxygen, sulphur or NR<1> then Ar is aryl substituted by phenoxy or substituted phenoxy or is a tricyclic heteroaryl group as hereinafter defined; and when W is CH2 and k is 2 the side chain -(CH2)nA(CH2)mAr is not alpha to the nitrogen atom, and salts thereof, have activity as calcium channel antagonists. Processes for preparing compounds (I) and compositions containing them are also described.