发明名称 |
METHOD OF PREPARING VICINAL AMINOALCOHOLS |
摘要 |
<p>DIR 0502 The present invention is concerned with the preparation of N-substituted vicinal aminoalcohol derivatives from the corresponding hydroxyl-protected cyanohydrin derivatives by successive partial reduction, transimination using a primary amine, reduction of the resulting imine and optional removal of the hydroxyl-protecting group. The products are obtained either as a racemate or in an optically pure form, depending upon the stereochemical composition of the starting cyanohydrin derivatives. The present invention is also concerned with certain new enantiomerically pure hydroxyl-protected vicinal aminoalcohols.</p> |
申请公布号 |
CA2088552(A1) |
申请公布日期 |
1993.08.05 |
申请号 |
CA19932088552 |
申请日期 |
1993.02.01 |
申请人 |
DUPHAR INTERNATIONAL RESEARCH B.V. |
发明人 |
BRUSSEE, JOHANNES;VAN DER GEN, ARNE;KRUSE, CHRIS G. |
分类号 |
C07B53/00;C07C213/00;C07C215/04;C07C215/24;C07C215/34;C07C217/08;C07C217/70;C07C233/36;C07C253/30;C07C255/26;C07C311/05;C07C317/28;C07C323/25;C07F7/18;(IPC1-7):C07F7/10;C07C215/08;C07C317/32;C07C217/28;C07C215/28;C07D307/20;C07D319/18;C07D309/12;C07D317/58;C07C255/59;C07C323/32 |
主分类号 |
C07B53/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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