发明名称 |
CRYSTALLINE MODIFICATION OF HYDROCHLORIDE OF 2-DIMETHYLAMINOETHYL ETHER OF n-BUTYLAMINO BENZOIC ACID, METHOD OF OBTAINING IT AND PHARMACEUTICAL PREPARATION FOR ANESTHESIA OF THE EYE BASED THEREUPON. |
摘要 |
A new crystalline modification of hydrochloride of 2-dimethylaminoethyl ether of n-butylamino benzoic acid is characterized by one endothermic melting effect at a temperature of 148.6 DEG +/- 0.3 DEG C and by the values of the interplane distances d and of relative intensities of reflexes (I). A method of obtaining said substance consists in that the solution of hydrochloride of 2-dimethylaminoethyl ether of n-butylamino benzoic acid of polymorphic form in the water or in an organic solvent or in their mixture is cooled by means of a cooling agent at a speed no less than 8 DEG C/min up to its full crystallization with subsequent drying of the thus obtained crystals. The claimed substance has local anesthesia properties and is an active agent of a pharmaceutical preparation for anesthesia of the eye (the content of the active substance from 0.05 to 0.5 percent by weight). |
申请公布号 |
EP0553351(A1) |
申请公布日期 |
1993.08.04 |
申请号 |
EP19910914958 |
申请日期 |
1991.08.19 |
申请人 |
VREMENNY MEZHOTRASLEVOI NAUCHNO-TEKHNICHESKY KOLLEKTIV "BIOEFFEKT" |
发明人 |
LEONIDOV, NIKOLAI BORISOVICH |
分类号 |
A61K9/08;A61K31/245;A61P23/00;A61P23/02;A61P25/02;A61P27/02;C07C227/38;C07C227/42;C07C229/60 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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