摘要 |
PURPOSE:To provide the subject liposome excellent in the controlled releasability for medicine, useful for cancer, tumor, etc., comprising dipalmitoylphosphatidyl- choline and negatively charged diacyl-glycerophosphatide at a specified proportion. CONSTITUTION:The objective liposome comprising (A) dipalmitoylphosphatidyl- choline and (B) a negatively charged 1,2-diacyl-glycerophosphatide (where, acyl groups at 1- and 2-sites are each palmitoyl or stearoyl independent of each other) at the weight ratio of (20:1) to (8:2). This liposome has the following characteristics: (1) the osmotic pressure ratio for inside aqueous phase is 1.5 to 2 times that for physiological isotonic liquid, and (2) particle diameter is 0.03-0.5mum. |