| 摘要 |
PURPOSE:To obtain the subject new anti-endotoxin compound useful for treating activation through a lipopolysaccharide (LPS) which serves as a medium for septic shocks, viral infectious diseases, etc. CONSTITUTION:The objective compound expressed by formula I [at least one of R<1> to R<4> is formula II, etc.; A<1> and A<2> are H, OH, OCH3, formula III (d is 0-5), etc.; X is H, (CH2)tCH3 (t is 0-14), (CH2)tOH, etc.; Y is H, OH, O(CH2)wCH3 (w is 0-14), halogen, etc.]. This compound expressed by formula I is obtained by reacting a mannopyranoside expressed by formula IV with a catalytic amount of naphthalene in the presence of lithium to provide a product, reacting the resultant product with ammonium cerium nitrate and an alkali metallic azide, then reacting the prepared product with sodium nitrate, further reacting the obtained product with lithium bis(trimethylsilyl)amide, etc.
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