| 摘要 |
Novel chroman derivatives of the formula I <IMAGE> in which X is O or NR11, Z is CH2, O, S or CHHal, R1 and R5 are each A, R2 is H or A, R1 and R2 together are also alkylene having 3-6 C atoms, R3 is OH or OAc, R4 is H, R3 and R4 together are also a bond, R6 and R7 are each H, A, HO, AO, CHO, ACO, ACS, HOOC, AOOC, AO-CS, ACOO, A-CS-O, hydroxyalkyl, NO2, NH2, NHA, NA2, CN, F, Cl, Br, I, CF3, ASO, ASO2, AO-SO, AO-SO2, AcNH, AO-CO-NH, H2NSO, HANSO, A2NSO, H2NSO2, HANSO2, A2NSO2, H2NCO, HANCO, A2NCO, H2NCS, HANCS, A2NCS, ASONH, ASO2NH, AOSONH, AOSO2NH, ACO-alkyl, nitro-alkyl, cyanoalkyl, A-C(=NOH) or A-C(=NNH2), R8 and R9 are each H or A or together are =O or =S, R10 is H, Hal, CHO or CH2OH, R11 is H, A, Ac or CH2OH, m is 1, 2 or 3, Hal is F, Cl, Br or I, A is alkyl having 1-6 C atoms, -alkyl is alkylene having 1-6 C atoms and Ac is alkanoyl having 1-8 C atoms or aroyl having 7-11 C atoms, and their salts show effects on the cardiovascular system.
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