Neuroblastoma-associated regulator gene

摘要

PCT No. PCT/EP92/02962 Sec. 371 Date Jun. 23, 1994 Sec. 102(e) Date Jun. 23, 1994 PCT Filed Dec. 19, 1992 PCT Pub. No. WO93/13205 PCT Pub. Date Jul. 8, 1993Described is a gene situated in the region of the neuroblastoma consensus deletion 1p36.2-p36.1 and which codes for a helix-loop-helix protein with the designation HEIR-1. The gene is affected significantly by allelic tumor deletions in neuroblastomas and correlates inversely both N-myc overexpression in tumors and with N-myc expression in normal development. The cDNA and antibodies coding for HEIR-1 are used for the diagnosis of pathological conditions associated with aberration in the region of the neuroblastoma consensus deletion.