| 摘要 |
A method of introducing a peptide into the cytosol by linking the peptide to a bacterial or plant toxin, or a mutant thereof. A method of preparing a vaccine by linking a peptide to a bacterial or plant toxin, or a mutant thereof to translocate the peptide into the cytosol for subsequent presentation at the cell surface by Class I MHC antigens to elicit a Class I restricted immune response and to expand the relevant population of CD8<+> T-lymphocytes. Vaccines produced by said method and the use thereof against viruses, intracellular bacteria and parasites, and against molecules associated with malignancies. |
