| 发明名称 |
NOVEL METHODS FOR PRODUCING ANTIGEN-SPECIFIC, HIGH-AFFINITY HUMAN MONOCLONAL ANTIBODIES |
| 摘要 |
The present invention relates to advances in monoclonal antibody production, and particularly, in culturing methodology preparatory to hybridoma formation. Specifically, retention of lymphoid fragments in the culture systems results in predominantly IgG-secreting, long-lived cultures. |
| 申请公布号 |
EP0533841(A4) |
申请公布日期 |
1993.07.28 |
| 申请号 |
EP19910912968 |
申请日期 |
1991.05.21 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
BOERNER, PAULA;ROYSTON, IVOR |
| 分类号 |
A61K39/395;A61K38/00;C07K16/00;C07K16/18;C07K16/42;C12N5/00;C12N5/02;C12N5/06;C12N5/10;C12N5/16;C12N5/24;C12N15/02;C12P21/08;C12R1/91 |
主分类号 |
A61K39/395 |
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