| 摘要 |
PYRROLIDINEAMIDE DERIVATIVE OF ACYLAMINO ACID AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME : A compound of the general formula: (1) wherein m is an integer of 1 to 7, n is 0 or an integer of 1 to 5, R1 is the phenyl, a substituted phenyl, the phenoxy, a substituted phenoxy or a saturated or unsaturated straight alkyl having 5 to 18 carbon atoms, R2 is hydrogen atom, R3 is hydrogen atom, a branched or unbranched alkyl having 3 to 5 carbon atoms, the phenyl, hydroxyphenyl, benzyloxyphenyl, an alkylthio having 1 to 3 carbon atoms in its alkyl moiety, amino, carboxyl, hydroxy, benzyloxy, indolyl or imidazolyl, or R2 and R3 together form a single bond between the carbon atom and the nitrogen atom, and a pharmaceutical composition containing said compound are provided. The compound is effective in curing amnesia because of its anti-prolyl endopeptidase activity. |
