MODIFIED ANTIBODY AND RECOMBINANT TO PRODUCE MODIFIED ANTIBODY

摘要

PURPOSE:To obtain a new antibody having increased bonding force to an antigen. CONSTITUTION:A human antibody wherein L chain among H chain and L chain is replaced with an L chain-like protein composed of domain VH, VL and CL. For example, HI223 antibody, H chain antibody gene and L chain antibody gene are simultaneously transduced to B lymphocyte and the gene is amplified to give a human antibody containing the L chain-like protein wherein VH domain V1 and C1 domains are connected as well as antibody H chain and L chain.