| 摘要 |
PURPOSE:To produce the subject enteric particle insoluble in the stomach, not dissolved till it reaches the intestine for exhibiting its bioactivity and capable of long-term storage without reduction of the bioactivity while preventing denaturation of the granulated substances due to adsorption of water or alcohol. CONSTITUTION:A bioactive substance such as Lactobacillus or Lactobacillus bifidus and functional materials such as a vegetable fiber easy to be denaturated by adsorption of water or alcohol during the production process and a vegetable protein are used for granulation. The above-mentioned substances are coated with three layers of (A) a long-term stabilizing layer containing fats and oils and a vehicle, (B) a fat and oil layer stable to water and alcohol and (C) a low pH zone-stabilizing layer containing a hydrous alcohol soluble protein, preferably zein in order, thus obtaining the objective enteric particle having the abovementioned effects. In addition, if the above-mentioned substances are coated with the (A) and (C) layers, the orally administrated substances are not dissolved in the gastric juice and dissolved in the intestinal digestive juice. A long-term stable storage is possible since the substances are not almost in contact with the air during storage. If the (B) layer is sandwiched between the (A) and (C) layers, the above-mentioned substances can be prevented from denaturation due to adsorption of water or alcohol in the production process. |
