Process for producing enyne derivatives

摘要

A process for producing an enyne derivative, and intermediate, which is useful for preparing compounds showing strong inhibiting activities against squalane.epoxidase of Eumycetes and strong anti-cholesterol activities. The process comprises reacting a compound of the formula: Z-CH2-CH=CH-W[I] wherein W is a halogen atom, and Z is a leaving group, with an amine in the presence of a base, if necessary, to obtain a compound of the formula: <IMAGE> [IV] then reacting an acetylene derivative to this compound in the presence of a palladium catalyst, to obtain a compound of the formula: <IMAGE> [VII] and, if necessary, N-alkylating this compound.