| 摘要 |
PURPOSE: To provide a blood preparation inactivated in relation to infectious substances, to provide a method for producing the preparation, and to provide a method for determining the virus inactivation capacity of the inactivation treatment. CONSTITUTION: This inactivated blood preparation is obtained (a) by treating a blood preparation in an aqueous solution containing a surfactant in an amount of at least 2%, preferably at least 5%, and subsequently thermally treating the product in a solid state or (b) by thermally treating the blood preparation in a solid state and subsequently treating the product in an aqueous solution containing a surfactant in an amount of at least 2%, preferably at least 5%. The inactivation treatment gives the blood preparation inactivated in relation to infectious substances, and having a whole virus decrease coefficient of at least 40 and a biological activity of at least 50% based on the activity before the inactivation of the infectious substances. The thermal treatment of the blood preparation in the solid and dry state is preferably carried out under a water content condition of 0.05-0.70. The method of determining the virus inactivation capacity of the inactivation treatment comprises repeatedly adding test viruses during the inactivation treatment and totalizing individual decrease coefficients to obtain the total virus decrease coefficient. |
